Safety and efficacy has not been established for Interferon gamma given in doses greater or less than the recommended dose of 50 mcg/m2. The unused portion of any vial should be discarded. A vial of Interferon gamma is suitable for a single use only. The formulation does not contain a preservative. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Interferon gamma can be administered by a physician, nurse, family member or patient when trained in the administration of subcutaneous injections. The optimum sites of injection are the right and left deltoid and anterior thigh. Injections should be administered subcutaneously three times weekly (for example, Monday, Wednesday, Friday). This is equivalent to what was previously expressed as units (1.5 million U/50mcg). Note that the above activity is expressed in International Units (1 million IU/50mcg). The recommended dosage of Interferon gamma for the treatment of patients with Chronic Granulomatous Disease and severe, malignant osteopetrosis is 50 mcg/m2 (1 million IU/m2) for patients whose body surface area is greater than 0.5 m2 and 1.5 mcg/kg/dose for patients whose body surface area is equal to or less than 0.5 m2. Pediatric Indications and Dosage FDA-Labeled Indications and Dosage (Pediatric) Dosage: 0.5 x 10^6 - 1.5 x 10^6 International Units (UI) IM 3 times a week for 12 weeks.Non–Guideline-Supported Use Atopic Dermatitis There is limited information regarding Off-Label Guideline-Supported Use of Interferon-gamma in adult patients. Off-Label Use and Dosage (Adult) Guideline-Supported Use Interferon gamma may be administered using either sterilized glass or plastic disposable syringes.Dose Modification: If severe reactions occur, the dosage should be reduced by 50 percent or therapy should be interrupted until the adverse reaction abates.Interferon gamma should not be mixed with other drugs in the same syringe. The minimum effective dose of Interferon gamma has not been established. The formulation does not contain a preservative.The recommended dosage of Interferon gamma for the treatment of patients with Chronic Granulomatous Disease and severe, malignant osteopetrosis is 50 mcg/m2 (1 million IU/m2) for patients whose body surface area is greater than 0.5 m2 and 1.5 mcg/kg/dose for patients whose body surface area is equal to or less than 0.5 m2.Common adverse reactions include Injection site pain, rash, nausea, vomiting, arthralgia, myalgia, headache, fatigue, fever and influenza-like illness.Īdult Indications and Dosage FDA-Labeled Indications and Dosage (Adult) Interferon-gamma is an immunological agent that is FDA approved for the treatment of serious infections associated with Chronic Granulomatous Disease and delaying time to disease progression in patients with severe, malignant osteopetrosis. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery.
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